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Peptides usually have unstable structures. To make SP9, the crew made use of a way identified as hydrocarbon stapling to freeze it in a very shape that blocks Syt2 from interacting With all the cell membrane proteins.
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Dickey's lab commenced studying mucin secretion two decades ago and previously discovered The true secret genes and proteins included, exhibiting how synaptotagmin and also a SNARE elaborate, comparable to that found in neurons, contribute to the key means of Ca2+-brought on membrane fusion.
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